$QSAM “OTC Stock Review” Promoter Rank: 24/27 QSAM Biosciences Inc. Newsletter 11:05:18 AM December 9, 2020

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QSAM Promotional Newsletter

The following is a newsletter released by "OTC Stock Review" promoting QSAM Biosciences Inc.

Caution

The following newsletter has not been verified for accuracy or completeness.

QSAM Biosciences Inc.

We have sent you some info on this company a couple of times. You had an opportunity to get in lower, but this stock could trade a lot higher. Here's why, after the first of the year QSAM plans to start Phase 1 trials with the FDA for CycloSam. There is no company in Phase 1 trials with less than a $50 million market cap. QSAM currently has about a $7 million market cap. Take a look at the management team and you will see this is not your typical OTC company . These guys are legit. I'm giving you an opportunity to get in before the fireworks start.

QSAM Bioscience, Inc. QSAM holds the worldwide license for CycloSam Samaium-153 DOTMP, a clinical stage novel radiopharmaceutical meant to treat different types of bone cancer and related diseases. This isnt just bone cancer. This drug could be used to treat OsteoSarcoma and Bone Metastasis. There has been no new treatment for OsteoSarcoma in the last 40 years. Forget about the fact that this is a billion dollar market. OsteoSarcoma and Bone Metastasis are both very common in Ewing Sarcoma, which is a cancerous tumor that grows in the bones, or in the tissue around bones, of children. The result is often amputation of the affected limb. QSAM could change this.

Read this great CEO Letter dated November 24, 2020 for more information on QSAM.

QSAM is expecting to start the FDA approval process for CycloSam after the first of the year. The market cap on this company is much lower than just about every other company in the FDA approval process. The great thing about CycloSam is that the FDA has already approved it as Quadramet, which is an injectable radiopharmaceutical used for pain relief in cancer patients suffering from osteoblastic metastatic bone lesions. QSAM will be looking for FDA approval on CycloSam as a chelate vehicle that carries the drug that can stop the growth of a tumor to the site of the growth.

This nuclear technology uses low specific activity Samarium-153 resulting in far less europium and DOTMP, a chelator which is believed to eliminate off-target migration and targets high bone turn over making it an ideal agent to treat OsteoSarcoma, bone metastases and to perform bone marrow ablation. Sm-153 DOTMP has been cleared by the FDA under an investigator initiated IND to commence human dosing of cancer patients. QSAM Therapeutics, Inc.

QSAM Therapeutics, Inc. QSAM, a wholly-owned subsidiary of QSAM Biosciences, Inc. OTCQB QSAM, is developing next generation nuclear medicines for the treatment of cancer and related diseases and conditions.

QSAMs initial technology is Samarium-153 DOTMP, aka CycloSam, a clinical-staged bone targeting radiopharmaceutical from IsoTherapeutics Group, leaders in the nuclear medicine space who also developed FDA-approved and commercially available Quadramet Samarium-153 EDTMP, indicated for pain palliation.

CycloSam has already demonstrated safety and efficacy in animal studies and a human trial performed at the prestigious Cleveland Clinic. This drug candidate utilizes an FDA approved radioisotope combined with a novel chelate that has demonstrated increased efficacy and decreased side effects in animal models. Further, CycloSam utilizes a streamlined, just-in-time manufacturing process. Given these factors, management believes there is a strong pathway to commercialization.

CycloSam is cleared by the FDA under an investigator IND to commence human dosing immediately in patients with osteosarcoma and bone metastasis. CycloSam was also cleared by FDA and successfully used under a single-patient IND to perform bone marrow ablation prior to allogenic marrow transplantation BMAT in 2020.

Interested investors can find out more about QSAM Biosciences, Inc. and the Companys wholly-owned subsidiary, QSAM Therapeutics, Inc. by visiting
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According to report published by Grand View Research, the global nuclear medicine market size was valued at USD 6.1 billion in 2019 and is estimated to witness a CAGR of 9.5%during the forecast period.

The global Nuclear Medicine Market size is expected to reach USD 12.6 billion by 2027, expanding at a CAGR of 9.5%, according to a new report by Grand View Research, Inc. Research and development of advanced technologies by the key players for diagnosis and treatment of diseases is expected to drive the radiopharmaceuticals market. QSAM Management

In our opinion, the reason you want to look at QSAM can be summed up in one word, management. You will not find a management team of this caliber in any other small cap company with a $7 million market cap. Doug Baum, the CEO, has been in drug development since 1991. He has provided FDA navigance on several drugs that are already on the market. Dr. Richard Piazza is the Executive Chairman and he has had four successful exits on biotech companies. These guys are rock stars. Im including their bios from the website We will be putting together a more extensive report and do a deeper dive into their background, but wanted to get the word out on QSAM.

Douglas R. Baum Chief Executive Officer, President and Director

Douglas R. Baum has 28 years of experience serving in a number of executive management and business development positions within the drug development and life sciences industries. Currently, he serves as the CEO, President and Director of QSAM and its subsidiary, QSAM Therapeutics, Inc., a company he co-founded in 2019. QSAM is an Austin, Texas based clinical stage specialty pharmaceutical company developing a pipeline of radiopharmaceuticals focused on various bone and solid tumor cancers.

Previously, Doug was the President and CEO of Xeris Pharmaceuticals Inc. NASDAQ XERS a specialty pharmaceutical company focused on developing drugs for diabetes and related metabolic diseases. Prior to Xeris he served as the COO of MacuCLEAR, a specialty pharmaceutical company developing novel treatments for retinal diseases of the eye. Prior to MacuCLEAR, Doug served as the Vice President, Global Corporate Development at Premier Research Group PRG, Inc. a global contract research organization serving the pharmaceutical, biotechnology and medical device industries. In 2007 PRG acquired SCIREX Corporation where Doug served as Executive Vice President General Manager, Early Drug Development. He also serves on the Board of Directors of Regent Technologies, Inc. and previously served on the boards of Xeris, MacuCLEAR, Halsa Pharmaceuticals, Inc. and the Texas Medical Device Alliance.

Doug obtained his Bachelors of Business Administration degree and his Masters of Science in Technology Commercialization degree from the University of Texas at Austin.

C. Richard Piazza, Ph.D. Executive Chairman

C. Richard Piazza, Ph.D. is a career healthcare executive with 48 years of experience in medical devices as well as the pharmaceuticalbiotechnology sectors. Included in this is 44 years in general management positions in both public and private international companies including Ohmeda, Smith Nephew Pharmaceuticals, Marquest VitaGen worlds first bioartifical liver. In 2019 he co-founded QSAM Therapeutics, Inc. with Doug Baum and currently serves as its Executive Chairman.

Richard has gained a reputation of not only introducing new technologies and driving them to success but recruiting and motivating world class, highly focused management teams. In addition to a highly successful business career, Richard has served on industry association boards committees Advamed, Biocomm, BioHouston etc. and was an industry representative working with the FDA and the Congress to craft the FDA Modernization Act for Medical Devices. His Board experience also includes numerous directorships and Chairman roles in both public and private healthcare companies. In addition to industry affiliations, Richard remains committed to working with well-known medical pioneers to identify and advance new technologies. He acts as an advisor to some of worlds leading institutions. These include MD Anderson Cancer Center, Baylor College of Medicine, University of California San Diego, University of Chicago Kings College Hospital London. Richard has been a guest Lecturer in Sales Marketing strategy at numerous Universities including Rice University School of Management, UCLA, University of Wisconsin, CAL Tech-MIT forum, University of British Columbia University of California San Diego.

Richard obtained a BS in Economics and a BS in Speech Pathology from the State University of New York and MA PhD in Economics from the University of Buffalo and Leeds University.

Barry Sugarman Senior Advisor

Barry Sugarman is a Senior Executive Generalist with over 30 years of experience spanning public and private companies in the pharmaceutical, medical device, dietary supplement, and cosmetic industries. Barry has considerable direct experience in pharmaceutical product development, manufacturing, clinical trials, regulatory affairs, FDA and government relations, marketing, and distribution.

Barry possesses broad experience in clinical trial operations and management, mergers, acquisitions, turnarounds, startups, reorganization, process improvements, and sales management and a very strong knowledge of Good Manufacturing Practices GMPs, Good Clinical Practices GCPs, Good Laboratory Practices GLPs, and International Conference for Harmonization ICH requirements. He is an author and co-author of numerous FDA filings and approvals including Investigational New Drug Applications INDs, New Drug Applications NDAs, Abbreviated New Drug Applications ANDAs, and Medical Device Applications 510ks.

Barry is a member of the Regulatory Affairs Professional Society , American Association of Pharmaceutical Scientists , Association of Clinical Research Professionals , and the National Association of Corporate Directors . He is a co-author of Prompt, Accurate Diagnosis of Pediatric Cancer and Leukemia for Pediatricians, Orthopedists, and Family Practitioners Paperback Aug. 28, 2007 by Andrew Pendleton, Jennifer Minigh, Lainie Shapiro, and Barry Sugarman.

R. Keith Frank, Ph.D. and Jim Simon, Ph.D. Scientific Advisory Board

Over 30 years experience each with Dow Chemical leading RD efforts in Radiopharmaceuticals Chelators
Developed Quadramet
Founded IsoTherapeutics in 2005 performing contract RD for Big Pharma with emphasis on radiolabeling
Authoredco-authored more than 100 scientific papers publications
Recognized as leading authorities in radiopharmaceuticals
60 Patents
Internationally recognized experts in radiopharmaceuticals
Extensive interaction with research institutions, investigators and hospitals

OTC Symbol QSAM

Current Price $0.47 x $0.52

Shares Outstanding 15,524,020

Restricted Shares 14,181,258

Unrestricted 1,342,762

Held at DTC 1,266,401

Float 914,666

Market Cap $6.99 million

52 Week Trading Range

52-Week Low $0.13

52-Week High $0.88

Corporate Offices

420 Royal Palm Way, 100,

Palm Beach, FL 33480

Contact Information

Website www.qsambio.com

Phone 561 693-1423

Company OfficersContacts

Douglas R. Baum Chief Executive Officer, President and Director

C. Richard Piazza, Ph.D. Executive Chairman

Barry Sugarman Senior Advisor

OTC Stock Review is not registered as an Investment Advisor or a BrokerDealer. The information in this newsletter is not an offer to buy or sell securities of the companies profiled. Information is for informative purposes, not intended as advice for investment and is subject to change without notice. OTC Stock Review has been compensated twenty five thousand dollars and one hundred and fifty thousand shares of QSAM common stock restricted under Rule 144 to perform investor relations services for QSAM. Officers and directors of OTC Stock Review may hold a long equity position in QSAM and may from time to time trade in these securities for their own accounts. Information on each company is from public releases and can not be guaranteed by OTC Stock Review. Companies profiled herein may carry a high investment risk readers should carefully review profiled companies thoroughly with their investment advisor, stockbroker, or other such professional. OTC Stock Review is not liable for any investment decisions by its readers or their advisors. Any analysis contained herein does not purport to be a complete analysis of the profiled Companies and reflects the opinion of the author. Readers should obtain copies of the profiled Companys periodic reports filed with United States Securities and Exchange Commission, generally available at or .

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