Citius Pharmaceuticals Inc.
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CTXR Promotional Newsletter
The following is a newsletter released by "Broad Street Alerts" promoting Citius Pharmaceuticals Inc.
Citius Pharma CTXR Enters an Agreement with Dr. Reddys to Acquire Investigational Anti-Cancer Agent E7777
Good day everyone,
We have been wondering what Citius Pharmaceuticals, Inc. NASDAQ CTXR might end up doing with the huge cash hoard of $115M Ive been telling you about the past couple months and the answer is now apparent.
Current price $2.10share at market close Friday, September 3, 2020
CTXR just entered into an agreement with Dr. Reddys NYSE RDY, to buy all its rights excluding Asia to E7777, an engineered IL-2-diphtheria toxin fusion protein and certain related assets used in the oncology sector as an anti-cancer agent.
Under the terms of agreement, Dr. Reddys will receive $40 million upfront upon the closing of the transaction, followed by approval milestone payments of up to $40 million related to the CTCL cutaneous T-cell lymphoma indication approval and up to $70 million for additional indication approvals. Further, Dr. Reddys will receive certain sales-based milestones and tiered earn-out payments.
Entry into the oncology sector with a viable anti-cancer agent could be a major catalyst for CTXR
Why invest in E7777
First, we need to recognize that the CTXR management, board of directors, and scientific advisory boards are made up of some of the best minds in medicine and would give significant due diligence and careful consideration to an investment of this magnitude.
E7777 has significant potential as an important component of systemic therapy for CTCL cutaneous T-cell lymphoma and other cancers. Its an established anti-cancer agent that has been the subject of clinical trials and pre-clinical studies both as a monotherapy and a combination therapy. In both situations E7777 has produced positive results.
I want to note that Dr. Reddys negotiated $70M in additional payments as E7777 is approved for other indication approvals beyond CTCL.
E7777 began clinical trials when it was being developed by Eisai Co. Ltd, a Tokyo company. Eisai sold E7777 to Dr. Reddys in 2016, excluding rights to Asia. A was initiated by Eisai in March of 2016 and was completed in 2019.
More recently, in November 2020, Dr. Reddys did a poster presentation at SITC with indicating that both E7777 and Anti-PD-1 both reduced tumors as monotherapies, but got substantially better results when combined.
The consummation of the RDY agreement will place CTXR solidly on the up-and-coming pharma companies list. Both Eisai mc $24.3B and Dr. Reddys mc $11.1B are significant players in pharma and E7777 I is an established anti-cancer agent. Both Eisai and Dr. Reddys invested in E777.
Eisai conducted positive monotherapy human trials before they sold to Dr. Reddys and decided to retain the rights in Japan and Asia. Dr. Reddys conducted pre-clinical combination studies and presented data at a major oncology conference before this transfer to CTXR.
We wont know CTXRs plans for this anti-cancer agent until they announce it, but the possibilities are exciting. I think the acquisition of E7777 may be a major catalyst for the company both in the near and mid-term. The addition of E7777 to the CTXR pipeline could make the company more interesting to institutional investors also.
I am writing this report over the holiday weekend and CTXR hasnt released the news of this agreement yet. All the information above is generated from Dr. Reddys press release and other publications. I will update you immediately when CTXR makes an announcement.
Stay tuned and stay informed. We will be updating this exciting development at CTXR.
For our newer members
About Citius Pharmaceuticals, Inc.
Citius is a late-stage biopharmaceutical company dedicated to the development and commercialization of first-in-class critical care products, with a focus on anti-infectives in adjunct cancer care, unique prescription products, and stem cell therapy. The Company's lead product candidate, Mino-Lok, an antibiotic lock solution for the treatment of patients with catheter-related bloodstream infections CRBSIs, is currently enrolling patients in a Phase 3 pivotal superiority trial. Mino-Lok was granted Fast Track designation by the U.S. Food and Drug Administration FDA. Through its subsidiary, NoveCite, Inc., Citius is developing a novel proprietary mesenchymal stem cell treatment derived from induced pluripotent stem cells iPSCs for acute respiratory conditions, with a near-term focus on acute respiratory distress syndrome ARDS associated with COVID-19.
More on CTXR coming soon.
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