$ATNM “Broad Street Alerts” Actinium Pharmaceuticals, Inc. Newsletter 7:00:01 AM October 22, 2020

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ATNM Promotional Newsletter

The following is a newsletter released by "Broad Street Alerts" promoting Actinium Pharmaceuticals, Inc.

Caution

The following newsletter has not been verified for accuracy or completeness.

Potential catalyst on the horizon...

Actinium ATNM Awarded Grant by NIH

Good day everyone,

We are continuing our coverage of, Actinium Pharmaceuticals, Inc. NYSE ATNM, a clinical stage biopharmaceutical company.

Current price $11.78 per share

Actinium shares opened at $11.17 per share on Wednesday, October 21, 2020, and quickly gained 8.5% to $12.12share.

Breaking News
Actinium Pharmaceuticals, Inc. Awarded Grant by National Institutes of Health to Study Novel Iomab-ACT Targeted Conditioning with a CD19 CAR T-Cell Therapy

The NIH has awarded Actinium a Small Business Technology Transfer grant to support a clinical collaboration with Memorial Sloan Kettering Cancer Center MSK to study Iomab-ACT, Actinium's CD45-targeting Antibody Radio-Conjugate, for targeted conditioning to achieve lymphodepletion prior to administration of a CD19-targeted CAR T-cell therapy developed at MSK. Memorial Sloan Kettering Cancer Center is a leader in cellular therapies to treat cancer.
For those of you who wish to read more about the science of the pending study, weve included the link below

Earlier we talked about ATNM trailing other companies, similar in scope, outpacing Actinium in market capitalization by a factor of 3-4X. The new NIH study validates even further the reasons ATNM should have a market cap on par with their peers.

Consider the ATMN recent and near-term potential catalysts

A new research facility focused on developing novel Antibody Radiation Conjugate ARC candidates, ARC therapeutic combination strategies, and supporting AWE platform research collaborations.

The new NIH grant in collaboration with Memorial Sloan Kettering Cancer Center.

Progress in their clinical trials. Iomab-B, which is being studied in a pivotal Phase 3 trial for targeted conditioning prior to a bone marrow transplant. The clinical trial has passed 50% enrollment and updated interim analysis from the study is anticipated soon Q4.

Announcement of a multicenter, open label Phase 12 trial of Actimab-A.

All the milestones listed above have occurred just in the past month. Combined with all the previous activity reported at ATNM, these new steps seem to indicate the company is transitioning into a much larger scale biopharma company.

The ATNM technology is currently directed at indications that cost the worldwide healthcare systems billions of dollars. Even with billions being spent to treat these patients, the outcome is too often lacking good results. ATNMs technology aims to increase the success rate for those indications.

The company shares remain significantly below their recent July high of $19.47 per share.

For those of you new to Actinium this is the process simply condensed

Antibody Radiation-Conjugates ARC combine the targeting ability of antibodies with the cell killing ability of radiation. The ATNM pipeline consists of ARCs targeted toward hematologic blood cancer indications.

Actinium's Antibody Warhead Enabling AWE platform. The power of this technology lies in its alpha emitting payload actinium-225. It emits a powerful dose of high energy but only over a very short distance - about the distance of a few cells or less than the thickness of a piece of paper. This focuses the radiation on the cancer cells and limits exposure to normal tissues.

The short, and overly simplistic explanation of the ATNM technology is that the ARCs seek out specific cancer and other specified cells and attach to them, allowing for a dose of actinium-225 radiation to destroy them.

The ATNM process is currently being evaluated in multiple blood cancer indications.

The Team
original report below
Good morning,

Update 102120 1033 AM EST- ATNM opened at $11.17 and has crossed $12.02 today for 7.5% in gains so far and building momentum

Actinium issued news this morning, more on this in our full report coming soon.

Actinium Pharmaceuticals, Inc. Awarded Grant by National Institutes of Health to Study Novel Iomab-ACT Targeted Conditioning with a CD19 CAR T-Cell Therapy -

The Team

_____________________________________________
Actinium ATNM is Advancing Twelve Products

Actinium has eight products currently in clinical trials.

Good day everyone,

Today we are revisiting a stock weve covered in the past, Actinium Pharmaceuticals, Inc. NYSE ATNM, a clinical stage biopharmaceutical company.

Current price $10.95 per share
Outstanding shares est. 13.59 million
Float est. 12.34 million shares

Considerations for ATNM shares

Twelve products in development.
Potential near-term catalyst.
Tiny share structure.
Trending shares.
Breakout chart set-up.

The companys lead product, Iomab-B via the monoclonal antibody BC8, targets CD45, an antigen widely expressed on leukemia and lymphoma cancer Jeff Bridges just announced he has this cells, B cells and stem cells.

Iomab-B is currently being studied in a Phase 3 trial, a 150-patient, randomized controlled clinical trial in patients with relapsed or refractory acute myeloid leukemia AML who are age 55 and above.

In a Phase 2 clinical study in 58 patients with advanced AML or high-risk myelodysplastic syndrome MDS age 50 and older, Iomab-B produced complete remissions in 100% of patients.

Additionally, ATNM has two products in phase 2 clinical trials, five products in phase 1 trials and four pre-clinical products. We included a link below if you want more information on Actinium clinical trial progress and product development

ATNM is gaining investor interest. Institutional investors now have a 13.9% stake in the company. We believe the institutions recognize that ATNM shares could be trading at a discount to their biopharma competition. ATNM has a current market cap of $150M. Lets look at some developmental biopharma companies, similar in scope to Actinium, to see how their market caps compare

XBiotech XBIT $548M
Atreca BCEL $525M
Applied Therapeutics APLT $485M
Odonate Therapeutics ODT $599M
Marinus Pharma MRNS $445M
Viking Therapeutics VKTX $408M

Recent News
Actinium announced last week, the launch of its new research and development lab facility in New York City. This new research facility expands Actinium's internal RD capabilities and will be focused on developing novel Antibody Radiation Conjugate ARC candidates, ARC therapeutic combination strategies, and supporting AWE platform research collaborations.

The new research facility is exciting news for ATNM and its stakeholders. Weve included a link below to the full press release by the company

Actinium's Antibody Warhead Enabling AWE platform, used for the delivery of the company products to cancer cells, may be a vertical for the company as well as its therapeutic products. The power of this technology lies in its alpha emitting payload actinium-225. It emits a powerful dose of high energy but only over a very short distance - about the distance of a few cells or less. This focuses the radiation on the cancer cells and limits exposure to normal tissues.

Actinium ended Q2 indicating it had $53M in cash. Capital expenditures aside, that cash runway could cover their cash burn for more than a year.

About
Actinium Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company developing ARCs or Antibody Radiation-Conjugates, which combine the targeting ability of antibodies with the cell killing ability of radiation. Actiniums lead application for our ARCs is targeted conditioning, which is intended to selectively kill patients cancer cells and certain immune cells prior to a BMT or Bone Marrow Transplant, CAR-T, and other cell therapies.

ATNM shares are trading 40% off their recent high of $19.47 established on July 27, 2020.

As the chart below indicates, ATNM shares have crossed their 50 DMA and 200 DMA of $9.48 and $8.75 respectively, in a bullish manner. ATNM shares are also leading their 20, 50, and 200 SMAs indicating a potential positive trend.

Full updated report coming soon,
The Team

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